Dr. Blaylock's 1999 letter to The LancetBy Neurosurgeon Russell Blaylock, M.D.
(c) 1999This article was formerly located at http://www.thelancet.com/newlancet/sub/discuss/TOP119/msg00001.html, but it has since been removed from their server
Re: Aspartame toxicity
Date Thu, 29 Jul 1999 23:07:04 +0100 (BST)
In reviewing the available literature on aspartame toxicity I have developed several concerns. First, is the results of the GD Searle study itself in 1977 which indicated a significant increase in brain tumor induction in the aspartame fed animals. This appeared to be secondary to a breakdown product, DKP. Follow up studies with DKP were seriously flawed, as demonstrated by the Bressler report. It should also be noted that other tumors appeared in the NutraSweet group including breast tumors, pancreatic tumors, testicular tumors, ovarian tumors and other tissues. Aspartame has been reported in association with a cutaneous panniculitis as well in human cases.
The recent study using radiolabeled aspartame that indicated attachment of the formaldehyde breakdown product to DNA and that the formaldehyde was cumulative with each dose should cause all of us concern. This is especially so in relation to oncogene activation and in disorders associated with elevated rates of DNA damage, such as lupus and the neurodegenerative disorders. I have found no studies relating to possible elevation of free radicals with aspartame exposure, but this certainly deserves review.
Shephard, et al found that aspartame was nitrosated in the GI tract and that in this form was significantly mutagenic. Such nitrosation, according to their findings, could also occur in endothelial cells and stimulated macrophages. This would raise concern not only of carcinogenic potential but also the stimulation of free radical generation in blood vessels associated with atherosclerosis. Related to this finding is another report by Hardcastle and Bruch, in which they found that macrophages treated with aspartame produced an excess of leukotrienes and other arachidonic acid metabolites. Yamada, et al found that aspartic acid inhibited melatonin secretion from the pineal gland. It has been shown that aspartame consumption does increase aspartic acid blood levels, especially when consumed with MSG.
Another concern is the formation of stereoisomer when aspartame is heated. Jeffry Bada has shown that when aspartame is heated there is a significant conversion of the L-phenylalanine and aspartate to the D- form. In addition, he found 6 to 10 decomposition products, some of which are known to have deleterious neurological effects. Elevated levels of D-aspartate have been described in several of the neurodegenerative diseases.
The effect of aspartame feeding on blood phenylalanine is of concern to the pregnant mother and those with newborns as well, since phenylalanine has been associated with abnormal neural connectivity in the immature brain. It has been established that PKU carriers develop phenylalanine blood levels double that of normals. Further, it has been shown that the placenta concentrates phenylalanine on the fetal side of the circulation. Matalon, et al demonstrated that in the human a loading dose of 34mg/kg increased phenylalanine levels greater than 6mg/dl in 14% of normals and 35% of PKU carriers. Of even more concern 5% of normals and 12% of carriers had blood Phe levels exceeding 10mg/dl. The National Collaborative Study for Maternal PKU has recommended that during pregnancy blood Phe should not exceed 6mg/dl. This means that 14% of the general public could exceed this level when consuming high intakes of aspartame and that 5% of normal people could exceed 10mg/dl. One in fifty persons carries a heterozygous gene for PKU. Up to 35% of such unfortunate individuals, and their babies, would be at risk without knowing it. Especially, since the babies brain levels would even exceed that of the mother.
With the complexity of the central nervous system it would be irresponsible for the FDA to allow the widespread selling of aspartame without further independent study of the neurophysiological, neurobehavioral and neurochemical effects of high intakes of this drug at all ages using chronic studies. I think it is foolish to ignore the complaints of millions of individuals reporting difficulties with this substance.
Russell L. Blaylock
USED BY PERMISSION OF THE AUTHOR
Click on photo for purchase information. Excitotoxins: The Taste That Kills (Paperback) by Russell L. BlaylockIt is almost a cliche in this day and age for someone to ask the waiter at a Chinese restaurant 'no MSG, please,' as is the waiter's knowing smirk in response. MonoSodium Glutamate (MSG), or 'The essence of taste' (as coined by the Japanese), is used as a 'taste-enhancer' in nearly every form of processed food on the market today, though 'taste addiction' may be a more correct term. But what exactly does it do? And how is it harmful?
Dr. Russell L. Blaylock answers these questions and poses some startling evidence as to the eventual consequences of a heavy MSG-diet in his book _Excitotoxins: The Taste that Kills_. In basic terms, MSG (and other, similar agents) pierces the blood-brain barrier and over-stimulates the neurons of a brain to a deadly degree. Habitual intake among animal experiments has shown the development of tumors, memory loss, and a whole host of neurodegenerative diseases as the end result of excess excitotoxin intake, including Alzhiemer's, Parkenson's, Lou Gerhig's etc.
Walk into any gas station in the United States (or grocery store, for that matter) and, upon close investigation, you will find that 75%-90% of the available food has been 'enhanced' to some degree by excitotoxins. The chemical agents are often disguised by such ambiguous terms as 'spice' and 'natural flavors' or, my personal favorite, 'hydrolyzed vegetable protein.' A consumer society must have consumer slaves to keep it functioning; MSG is the crack cocaine of the food industry...and it is legally perpetuated by slush-fund advocates and a pork-glutted FDA. As proven again and again, money talks, ... [you can finish the maxim for me].
Blaylock's thesis is written in a technical style, but the use of repetition throughout each chapter hammer in his myriad points into the reader with precision and power. An important book for anyone concerned with the health of self and family. You are what you eat---but do you know _what_ it is you are eating, below the surface of taste/fulfillment?
If you or someone you know
drinks diet soda check out the
Aspartame Victims Support Group at